IBU ratiopharm Lysinate pain tablets 500 mg, 10 pcs

Upute za korištenje IBU ratiopharm Lysinate pain tablets 500 mg, 10 pcs

Important notes (compulsory information):

IBU ratiopharm Lysinate pain tablets 500 mg, film-coated tablets. Active substance: Ibuprofen DL-lysine (1: 1). Applications: For slight to moderately strong pain, acute headache in migraine with and without aura and fever.

For risks and side effects, read the package leaflet and ask your doctor or pharmacist.



LEAFLET: INFORMATION FOR THE USER

IBU ratiopharm Lysinate pain tablets 500 mg, film-coated tablets for use in adolescents from 12 years and adults
Active ingredient: ibuprofen DL-lysine (1: 1)

Read the entire leaflet carefully before you start taking this medicine because it contains important information. Always take this medicine as described in this leaflet or just as your doctor or pharmacist is directed.

• Lift the package leaflet. You might want to read it again.
• Ask your pharmacist if you need more information or advice.
• If you notice side effects, contact your doctor or pharmacist. This also applies to side effects that are not indicated in this leaflet. See section 4.
• If the complaints worsen or after 3 days of migraine headaches as well as teenagers or 4 days of pain treatment and fever in adults no improvement occurs, they must definitely visit a doctor.

What is in this leaflet:
1. What is ibu-ratiopharm lysinate painkarts 500 mg and what is it used for?
2. What should you pay attention to 15 mg before taking IBU-ratiopharm lysinate?
3. How is IBU-ratiopharm lysinate pain tablets to take 500 mg?
4. Which side effects are possible?
5. Content of the pack and further information

1. What is ibu-ratiopharm lysinate painkarts 500 mg and what is it used for?

IBU ratiopharm Lysinate pain-tablets 500 mg is an anti-inflammatory and analgesic medicine (non-steroidal anti-phlogistikum / analgesic). IBU ratiopharm Lysinate pain-tablets 500 mg is used in light to moderately strong pain, acute headache at migraine with and without aura and fever.

2. What should you pay attention to 15 mg before taking IBU-ratiopharm lysinate?

IBU ratiopharm Lysinate pain tablets 500 mg must not be taken,

• if you allergic against ibuprofen or one of the section 6. mentioned other ingredients of this medicine are,
• when in the past they reacted with asthma attacks, nasal mucosal swellings or skin reactions after taking acetylsalicylic acid or other non-steroidal anti-steroids,
• with unexplained blood formation,
• for existing or past stomach / duodenum ulcers (peptic ulcera) or bleeding (at least 2 different episodes of proven ulcers or bleeding),
• in gastrointestinal bleeding or breakthrough (perforation) in the history associated with a previous therapy with non-steroidal antirheumatics / anti-phlogistika (NSAR),
• in cerebral bleeding (cerebrovascular bleeding) or other active bleeding,
• in heavy liver or renal impairment,
• with severe heart muscle weakness (heart failure),
• in the last third of pregnancy,
• from children under 12 years, since the active ingredient content is too high. For this age group, other ibuprofen preparations with lesser drug concentration are available.

Warnings and Precautions:
Please talk to your doctor or pharmacist before you IBU- ratiopharm Take lysinate pain tablets 500 mg.

Safety in the gastrointestinal tract:
A simultaneous applicationnG of IBU ratiopharm Lysinate pain tablets 500 mg with other non-steroidal anti-inflammatory inhibitors, including so-called COX-2 inhibitors (Cycloxigenase-2 inhibitors) should be avoided. Side effects can be reduced by applying the lowest effective dose to the shortest time required for symptom control. Elderly patients: In older patients, adverse effects after the application of non-steroidal anti-inflammatory anti-inflammatory effects, in particular bleeding and breakthroughs in the gastrointestinal and intestinal area, which may may be life-threatening. Therefore, in older patients, a particularly careful medical monitoring is required. Bleeding of the gastrointestinal tract, ulcers and breakthroughs (perforations): Bleeding of the gastrointestinal tract, ulcers and perforations, even with fatal output, were reported during treatment with all NSAs. They occurred with or without prior warning symptoms or Serious events in the gastrointestinal tract in the prehistory at any time of therapy. The risk for the occurrence of gastrointestinal bleeding, ulcers and breakages is higher with increasing NSAR dose, in patients with ulcers in prehistory, especially with the complications of bleeding or breakthrough (see "IBU ratiopharm Lysinate pain-tablets 500 mg must not be taken "), and in older patients. These patients should start treatment with the lowest available dose. For these patients as well as patients receiving accompanying therapy with low-metered acetylsalicylic acid (ASS) or other medicines that may increase the risk of gastrointestinal diseases require combination therapy with gastric mucosal protective medicinal products (e.g., misoprostol or proton pump inhibitor) are considered. If you have a history of side effects on the gastrointestinal tract, especially at higher age, you should report any unusual symptoms in the abdomen (especially gastrointestinal bleeding), especially at the beginning of the therapy. Caution is advised if they at the same time gain drugs that can increase the risk of ulcers or bleeding, e.g. Oral corticosteroids, blood clotting drugs such as warfarin, selective serotonin resumption inhibitors, which are used, among other things, for the treatment of depressive moods or thrombocyte aggregation inhibitors such as ass (See "Taking IBU ratiopharm lysinate pain tablets 500 mg along with other medicines"). If it is with you during treatment with IBU ratiopharm Lysinate pain-tablets 500 mg comes to gastrointestinal bleeding or ulcers, the treatment is to be deducted. NSAR should be in patients with a gastrointestinal disease in the prehistory (Colitis ulcerosa, Crohn's disease) To be careful, as your condition can deteriorate (see 4. "Which side effects are possible?“).

Effects at the cardiovascular system:
Anti-inflammatory means / painkillers such as ibuprofen can be accompanied by a slightly increased risk for a heart attack or stroke, especially when used in high doses. Do not exceed the recommended dose or duration of treatment (a maximum of 3 days in migraine headaches as well as teenagers and 4 days in adults). You

should treat.
your treatment before taking IBU ratiopharm Lysinat ache tablets 500 mg with your doctor or pharmacist discuss if you.

• a heart disease, including heart failure (Heart failure) and angina (chest pain), have or a heart attack, a bypass operation, a peripheral arterial sealing disease (circulation disorders in the legs or feet due to narrowed or sealed arteries) or any kind of stroke (including mini-stroke or transitory ischemic attack , "TIA:
• Hypertension, diabetes or high cholesterol levels or have heart disease or strokes in their family trial or when they are smokers

Skin reactions:
Under NSAR therapy was very rare about serious skin reactions with redness and blistering, some with fatal exit, reported(exfoliative Dermatitis, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis / Lyell Syndrome, see page 4. "Which side effects are possible?"). The highest risk of such reactions seems to be at the beginning of therapy, as these reactions occurred in the majority of cases in the first treatment month. The first sign of rashes, mucosal defects or other signs of a hypersensitivity reaction should IBU- ratiopharm Lysinat Senior Tablets 500 mg sold and the doctor will be consulted immediately. During a windpox infection (varicella infection) Should be an application of IBU ratiopharm Lysinat ache tablets 500 mg are avoided.

Other notes:
IBU ratiopharm Lysinate pain tablets 500 mg should only be applied under strict balance of benefit risk ratio:

• in certain innate blood formation disorders (e.g., acute intermittent porphyria),
• for certain autoimmune diseases (systemic lupus erythematosodes and mixing collagenosis).

A particularly careful medical monitoring is required:

• directly after larger surgical procedures,
• at allergies (eg skin reactions on other medicines, asthma, hay fever), chronic nasal mucosa thresholds or chronic respiratory respiratory respiratory diseases,
• with impaired renal or liver function.

Heavy acute hypersensitivity reactions (e.g., anaphylactic shock) are very rarely observed. For first signs of a hypersensitivity reaction after taking IBU ratiopharm Lysinate pain tablets 500 mg must be stopped therapy. The symptoms corresponding, medically necessary measures must be initiated by expert persons. Ibuprofen, the effective principle of IBU ratiopharm Lysinate pain-tablets 500 mg, can temporarily inhibit the platelet function (thrombocyte aggregation). Patients with blood clotting disorders should therefore be carefully monitored. If you simultaneously take medicinal products for inhibiting blood clotting or reducing blood sugar, precautionary controls of blood clotting or blood sugar levels should take place. For longer permanent administration of ibu ratiopharm Lysinate pain tablets 500 mg is a regular control of liver values, renal function and blood image required. When taking IBU ratiopharm Lysinate pain-tablets 500 mg Before surgical interventions, the doctor or dentist should be consulted or informed. The longer application of any kind of painkillers against headaches can aggravate these. If this is the case or this is suspected, medical advice should be obtained and treatment can be broken off. The diagnosis of headache in drug use (Medication Overuse Headache, MOH) should be suspected in patients who suffer from frequent or daily headaches, though (or just because) they regularly occupy medicines against headaches. Generally, the habitual intake of painkillers, especially when combining several analgesic agents, for permanent kidney damage with the risk of renal failure (analgesics nephropathy) to lead.

Children and adolescents:
Please note the instructions under "IBU ratiopharm Lysinate pain-tablets 500 mg must not be taken ". There is a risk for renal impairment in dehydrated adolescents.

Taking IBU ratiopharm Lysinate pain tablets 500 mg along with other medicines:
Inform your doctor or pharmacist if you take / use other medicines, recently taken / applied / applied / use other medicines. IBU ratiopharm Lysinate pain tablets 500 mg can affect or affect other medicines. For example:

• Drugs that work at temperate (i.e., the blood dilute / blood coagulation Veve, e.g. acetylsalicylic acid, warfarin, ticlopidine),
• Medicines that reduce high blood pressure (ACE inhibitors such as e.g. Captopril, beta-blockers such as Zenolol-containing medicines, angiotensin II receptor antagonists such as e.g. Losartan)

Therefore, you should always catch up with medical advice before using ibuprofen simultaneously with other medicines. Ibuprofen can enhance the effect of blood clotting resources such as warfarin, ticlopidine, phenprocoumon and heparin. Ibuprofen may attenuate the effect of ACE inhibitors (medium for the treatment of heart failure and hypertension) as well as the thrombocyte aggregation inhibiting effect of low-dose acetylsalicylic acid. With simultaneous use of IBU ratiopharm Lysinate pain tablets 500 mg and ACE inhibitors can continue to increase the risk of kidney function malfunction. Some other medicines can treat the treatment with IBU ratiopharm Lysinate pain-tablets 500 mg also affect or impaired by such a self. You should therefore prior to the use of IBU ratiopharm Lysinat painkarts 500 mg together with other medicines always obtain the advice of your doctor or pharmacist. The simultaneous application of IBU ratiopharm Lysinat ache tablets 500 mg and digoxin (medium to strengthen heart power), phenytoin (Means for the treatment of convulsive attacks) or lithium (agent for the treatment of spiritual-mental illnesses) can increase the concentration of these medicines in the blood. A control of serum lithium mirrors, the serum digoxin and serum phenytoin mirror is when used as intended (Maximum over 3 days in migraine headaches as well as for adolescents and 4 days in adults) usually not required. IBU ratiopharm Lysinate pain-tablets 500 mg can be the effect of dewatering medicines (diuretics) To weaken. The simultaneous administration of IBU ratiopharm Lysinate pain tablets 500 mg and potassium-saving drainage agents (Certain diuretics) can lead to an increase in the potassium mirror in the blood. The simultaneous administration of IBU ratiopharm Lysinate pain-tablets 500 mg with other inflammatory and pain-reset resources from the group of non-steroid antiphlogistics or with glucocorticoids increases the risk of gastrointestinal ulcers or bleeding. Thrombocyte aggregation inhibitors such as acetylsalicylic acid and certain antidepressants (selective serotonin recording inhibitors / SSRI may increase the risk of gastrointestinal bleeding. The administration of IBU ratiopharm lysinate pain tablets 500 mg within 24 Hours before or after administration of methotrexate can lead to an increased concentration of methotrexate and an increase in its undesirable effects. The risk of a kidney-damaging effect by Ciclosporin (means used to prevent graft fusions, but also in rheumatic treatment) is increased by the simultaneous administration of certain non-steroidal anti-phlogistics. This effect can not be excluded for a combination of Ciclosporin with ibuprofen. Medicines containing sampleecide or sulfinpyrazone (agent for treatment of gout) can delay the excretion of ibuprofen. This can lead to an enrichment of ibuprofen in the body with reinforcement of its undesirable effects. Clinical studies have shown interactions between non-steroidal anti-phlogistics and sulfonylureas (means for reducing blood sugar). Although interactions between ibuprofen and sulfonylureas are previously not described, a check of blood sugar levels is recommended with simultaneous use. Tacrolimus: The risk of kidney damage is increased when both drugs are administered simultaneously. Zidovudin.

There is evidence of increased risk of bleeding in joints (hemarthroses) and hematomas in HIV-positive hemophilia patients (blood) that simultaneously apply zidovudine and ibuprofen:

Taking IBU ratiopharm Lysinate pain tablets 500 mg together with alcohol.
During the application of IBU ratiopharm Lysinat ache tablets 500 mg If you do not drink alcohol as possible:

Pregnancy, lactation and reproductive capability
If youare pregnant or breastfeeding, or if you suspect to be pregnant or intend to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.

Pregnancy:
Will be used during the application of IBU ratiopharm Lysinate pain-tablets 500 mg detected a pregnancy, so the doctor is notified. You may only use ibuprofen in the first and second pregnancy a third party after consultation with your doctor. In the last third of pregnancy may ibu- ratiopharm Lysinate pain-tablets 500 mg are not applied because of an increased risk of complications for mother and child.

Latving:
The drug ibuprofen and its degradation products only go into the breast milk in small amounts. Since disadvantageous consequences for the infant have not become known so far, a short-term application is not required to interrupt the breastfeeding. If a longer ingestion of higher doses is prescribed, but an early deselectric should be considered.

Reproductive ability:
IBU ratiopharm Lysinate pain-tablets 500 mg belongs to a group of medicines (non-steroidal anti-rheumatics), which can affect the fertility of women. This effect is reversible (reversible) after discontinuation of the medicament).

Driving and ability to operate machines:
Because when using IBU ratiopharm Lysinat ache tablets 500 mg in higher dosing Central nervous side effects such as fatigue and dizziness may occur, in individual cases, the reaction assets can be changed and the ability to actively participate in road traffic and the operation of machines can be affected. This applies even more in combination with alcohol. You can then no longer respond to unexpected and sudden events quickly and specifically enough. Do not drive car or other vehicles in this case. Do not operate any tools or machines. Do not work without a safe grip.

3. What is ibu-ratiopharm lysinate to take pain tablets 500 mg?

Always take this medicine exactly as described in this leaflet or just according to the consultation made with your doctor or pharmacist. Ask your doctor or pharmacist if you are not sure. The recommended dose is: To achieve the analysis and fever: the recommended single dose for young people from 15 years and adults is 342 to 684 mg ibuprofen dlysin (1: 1) (corresponding to 200 mg to 400 mg ibuprofen). The total daily dose should not exceed approx. 2040 mg ibuprofen dlysine (1: 1) (corresponding to 1200 mg ibuprofen) and distributed to 2 - 4 individuals over the day. For young people from 12 years to 15 years, the recommended daily dose is about 34 to approx. 50 mg ibuprofen DL-lysine (1: 1) per kg body weight (kg)
(corresponding to 20 to 30 mg ibuprofen per kg body weight), Distributed to 3 - 4 individuals. Teenagers from 12 years (from 40 kg kg): single dose 1 film tablet (corresponding to 500 mg ibuprofen dlysin 1: 1 or about 300 mg ibuprofen), Total daily dose 2 - 3 film-coated tablets (corresponding to 1000 - 1500 mg ibuprofen dlysin 1: 1 and 600 to approx. 900 mg ibuprofen). Teenagers from 15 years and adults: single dose 1 film tablet (corresponding to 500 mg ibuprofen dllysin 1: 1 or approx. 300 mg ibuprofen), daily dose to 4 film-coated tablets (according to 2000 Mg ibuprofen dlysin 1: 1 or up to approx. 1200 mg ibuprofen). If you take a single dose, wait at least 6 Hours until next time.

Type of application:
Please take the film-coated tablets so far with plenty of fluid (e.g., a glass of water) during or after a meal. If you have a sensitive stomach, it is recommended that IBU ratiopharm Lysinat pain tablets 500 mg during meals. Take ibu ratiopharm Lysinate pain tablets 500 mg according to the instructions of the physician or according to the dosage instructions specified in the leaflet. If you feel, do not feel sufficient pain relief, then do not even increase the dosage independently, but ask your doctor.

Duration of application:
For fever and pain, the treatment time depends on DEm respondent complaint. If young people is required to take this medicine for more than 3 days or if the symptoms worse, medical advice should be obtained. In adults, treatment should be treated with IBU ratiopharm Lysinate pain tablets 500 mg without medical or dental council in migraine headaches 3 days and other pain and fever 4 days do not exceed. If the complaints exist beyond this period, please consult with your doctor. Please talk to your doctor or pharmacist if you have the impression that the effect of IBU ratiopharm Lysinate pain tablets 500 mg is too strong or too weak.

If you have a larger amount of IBU ratiopharm Lysinate pain tablets have taken 500 mg than you should:
As symptoms of overdose, central nervous disturbances such as headaches, dizziness, dizziness and unconsciousness can (In children also convulsions) as well as abdominal pain, nausea and vomiting occur. Furthermore, bleeding in the gastrointestinal tract and functional disorders of liver and kidneys are possible. Furthermore, it can cause blood pressure drop, reduced breathing (Respiratory depression) and to the blorus coloring of skin and mucous membranes (cyanosis) come. There is no specific antidote (antidote). When suspected of overdose with IBU ratiopharm Lysinat Senior Tablets 500 mg Please notify your doctor. This may decide according to the severity of poisoning over the necessary measures.

If you take the intake of IBU ratiopharm Lysinat ache tablets Forgot 500 mg:
Do not take the double amount when you forget the previous taking.

If you have further questions about taking this medicine, contact your doctor or pharmacist.

4. Which side effects are possible?

Like all medicines, this medicine can also have side effects, but they do not have to occur each other. If you are watching the following side effects, please discuss this with your doctor who determines how to proceed. The enumeration of the following undesirable effects includes all known side effects under treatment with ibuprofen, including those under high-dose long-term therapy for rheumatist. The frequency information that goes beyond very rare messages relate to the short-term application up to daily doses of a maximum of 1200 mg ibuprofen for oral dosage forms and a maximum of 1800 mg for suppositories. The following undesirable pharmaceutical effects must be taken into account that they are predominantly dose-dependent and patient to patient. The most frequently observed side effects involve the digestive tract. Stomach / duodenum ulcers (peptic ulcera), perforations (Breakthroughs) or bleeding, sometimes fatal, can occur, especially in older patients (see 2. Under "Warnings and Precautions"). Nausea, vomiting, diarrhea, bloating, constipation, digestive complaints, abdominal pain, teery chair, bleeding, ulcerative stomatitis, aggravation of colitis and crohn's disease (see 2. Under "Warnings and Precautions") have been reported according to application. Less often a gastric mucosal inflammation was observed. In particular, the risk of the occurrence of gastrointestinal bleeding depends on the dose range and the application time. Edema, hypertension and heart failure were reported in connection with NSAR treatment. Medicines such as IBU ratiopharm Lysinat ache tablets 500 mg may be associated with a slightly increased risk of cardiac attacks ("heart attack") or strokes.

Further side effects:
Frequently (can concern up to 1 of 10 treated):

• Gastrointestinal complaints such as heartburn, abdominal pain, nausea, vomiting, bloating, diarrhea, constipation and minor gastrointestinal blood losses that can cause anemia (anemia) in exceptional cases. If stronger pain in the upper abdomen, bruising, blood in the chair and / or a black staining of the chair occur, so you need ibu ratiopharm Lysinatesetting up Merztabletten 500 mg and immediately inform the doctor.

Occasionally (can concern up to 1 of 100 treated):

• Central nervous disturbances such as headaches, dizziness, insomnia, excitement, irritability or fatigue.
• Visual disorders.
• Stomach / duodenal ulcer (peptic ulcera), under certain circumstances with bleeding and breakthrough. Oral mucosal inflammation with ulcerator (ulcerative stomatitis), reinforcement of a colitis ulcerosa or a crohn's disease, gastric mucosal inflammation (Gastritis). If stronger pain in the upper abdomen, bruising, blood in the chair and / or a black staining of the chair occur, so you need ibu ratiopharm Split lysinate pain tablets 500 mg and inform the doctor immediately.
• Hypersensitivity reactions with rashes and skinchilden as well as asthma attacks (possibly with blood pressure drop). In this case, the doctor must be informed immediately, and IBU ratiopharm Lysinate pain tablets 500 mg may no longer be taken.

Rarely (can concern up to 1,000 treated):

• Earritis (tinnitus), hearing disorders.

Very rare (can be up to 1 out of 10,000 treated):

• Palpitations (palpitations), edema (liquid deposits), Heart muscle weakness (heart failure), heart attack.
• Disruptions of blood formation (anemia, leukopenia, thrombocytopenia, tank tops, agranulocytosis). First signs may be: fever, sore throat, superficial wounds in the mouth, influenza-like complaints, strong shock, nosebleed and skin bleeding. In these cases, the medicine must be stopped immediately and seek the doctor. Any self-treatment with pain or fever-cut medicines should be omitted.
• Inflammation of the esophagus (esophagitis) and the pancreas (pancreatitis). If stronger pain in the upper abdomen, bruising, blood in the chair and / or a black staining of the chair occur, so you need ibu ratiopharm Split lysinate pain tablets 500 mg and inform the doctor immediately.
• Training of membrane-like constrictions in thin and solid (Intestinal, diaphragmatic strictures).
• Increased water storage in the tissue with training of Ödemen, in particular in patients with high blood pressure or impaired renal function; Nephrotic syndrome (Water collection in the body edema and strong protein excretion in the urine); Flammable kidney disease (interstitial nephritis), which can be accompanied by an acute kidney function disorder. There can also be kidney taste damage (papilla nephroes) and increased urinary acid concentrations in the blood. Reduction of urinary excretion, accumulation of water in the body (edema) and general malaise can be expression of kidney disease to renal failure. If the symptoms mentioned occur or worse, so you need ibu- ratiopharm Split lysinate pain tablets 500 mg and contact your doctor immediately.
• Heavy skin reactions such as rash with redness and blistering (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis / Lyell syndrome, hair loss / alopecia. In exceptional cases, there may be an occurrence of heavy skin infections and soft tissue complications during a windpox disease (Varicelle infection) come (see also "infections and parasitic diseases").
• In the timing with the application of certain anti-inflammatory medicinal products (non-steroidal anti-inflammatory, IBU ratiopharm lysinate pain-tablets 500 mg), a deterioration of infectious inflammation (e.g., developing a necrotizing fasciitis) has been described. If during the application of IBU ratiopharm Lysinate pain-tablets 500 mg signs of an infection (e.g., redness, swelling, overheating, pain, fever) occur or aggravate, therefore, should the doctor be consulted immediately.
• Under the use of ibuprofen, the symptoms of a brain inflammation (ASEPtable Meningitis) How strong headaches, nausea, vomiting, fever, neck stiffness or consciousness observed. An increased risk seems to be for patients who already suffer from certain autoimmune diseases (systemic lupus erythematoses, mixing collagenosis.
• Hypertension (arterial hypertension).
• Heavy general hypersensitivity reactions. You can express yourself as: swelling of face, tongue and inner larynx with clinication of airways, air groove, heart hunt, blood pressure drop to the threatening shock. If one of these phenomena, which can already occur with initial application, immediate medical assistance is required and you may be allowed IBU- ratiopharm Lysinate pain tablets 500 mg no longer take.
• Liver dysfunctions, liver damage, especially during long-term therapy, liver failure, acute lifetitis (Hepatitis).
• Psychotic reactions, depression.

6. Content of the pack and further information

What ibu- ratiopharm Lysinate pain tablets 500 mg contains:
The active ingredient is ibuprofen DL-lysine (1: 1). Each film tablet contains 500 mg of ibuprofen DL-lysine (1: 1) (corresponding to 292.6 mg ibuprofen). The other ingredients include: microcrystalline cellulose, hypromellosis, croscarmello sodium, glycerol, magnesium stearate (ph.eur), macrogol 6000, talc, high-disperses silicon dioxide.

Like ibu- ratiopharm Lysinate pain tablets 500 mg looks and content of the pack:
White to slightly yellowish, grayish marbled, elongated film tablet with double-sided breaker. IBU ratiopharm Lysinate pain tablets 500 mg is in packs of 10 and 20 Film tablets available.

This information information was last revised in November 2015.

Source: Information of the leaflet
Status: 10/2016